Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition

Target competition (ceRNA crosstalk) within miRNA-regulated gene networks has been proposed to influence biological systems. To assess target competition, we characterize and quantitate miRNA networks in two cell types. Argonaute iCLIP reveals that hierarchical binding of high- to low-affinity miRNA...

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Bibliographic Details
Main Authors: Bosson, Andrew David, Zamudio, Jesse Ray, Sharp, Phillip A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/106343
https://orcid.org/0000-0003-1465-1691