Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

Since the discovery of NAD-dependent deacetylase activity of the silent information regulator-2 (SIR2) family (‘sirtuins’), many exciting connections between protein deacetylation and energy metabolism have been revealed. The importance of sirtuins in the regulation of many fundamental biological re...

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Bibliographic Details
Main Authors: Imai, Shin-ichiro, Guarente, Leonard Pershing
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/106460
https://orcid.org/0000-0003-4064-2510