Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase

Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase

Carbapenems, 'last-resort' β-lactam antibiotics, are inactivated by zinc-dependent metallo-β-lactamases (MBLs). The host innate immune response withholds nutrient metal ions from microbial pathogens by releasing metal-chelating proteins such as calprotectin. We show that metal sequestratio...

Full description

Bibliographic Details
Main Authors: González, Lisandro J, Bahr, Guillermo, Bonomo, Robert A, Vila, Alejandro J, Nakashige, Toshiki George, Nolan, Elizabeth Marie
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/106474
https://orcid.org/0000-0002-6234-8155
https://orcid.org/0000-0002-6153-8803

Internet

http://hdl.handle.net/1721.1/106474
https://orcid.org/0000-0002-6234-8155
https://orcid.org/0000-0002-6153-8803

Similar Items