High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we find that high fat diet (HFD)-induced obesity augments the numbers and function of Lgr5[superscript +] intestinal stem-cells (ISCs) of the mammalian intestine. Mechanistically, HFD induces a robust...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2017
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Online Access: | http://hdl.handle.net/1721.1/106594 https://orcid.org/0000-0002-5516-4008 https://orcid.org/0000-0001-6093-7282 https://orcid.org/0000-0002-1446-7256 https://orcid.org/0000-0002-7577-4612 |