Reverse Electron Transfer Completes the Catalytic Cycle in a 2,3,5-Trifluorotyrosine-Substituted Ribonucleotide Reductase

Escherichia coli class Ia ribonucleotide reductase is composed of two subunits (α and β), which form an α2β2 complex that catalyzes the conversion of nucleoside 5′-diphosphates to deoxynucleotides (dNDPs). β2 contains the essential tyrosyl radical (Y[subscript 122][superscript •]) that generates a t...

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Bibliographic Details
Main Authors: Ravichandran, Kanchana, Minnihan, Ellen Catherine, Wei, Yifeng, Stubbe, JoAnne, Nocera, Daniel G., 1957-
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2017
Online Access:http://hdl.handle.net/1721.1/106601
https://orcid.org/0000-0001-5050-9719
https://orcid.org/0000-0002-8683-3593
https://orcid.org/0000-0001-8076-4489