An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

The mitochondrial electron transport chain (ETC) enables many metabolic processes, but why its inhibition suppresses cell proliferation is unclear. It is also not well understood why pyruvate supplementation allows cells lacking ETC function to proliferate. We used a CRISPR-based genetic screen to i...

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Bibliographic Details
Main Authors: Freinkman, Elizaveta, Wang, Tim, Chen, Walter W., Abu-Remaileh, Monther, Sabatini, David, Birsoy, Kivanc
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/106636
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/106636
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-1446-7256

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