Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine

Hexameric ATP-dependent proteases and protein remodeling machines use conserved loops that line the axial pore to apply force to substrates during the mechanical processes of protein unfolding and translocation. Whether loops from multiple subunits act independently or coordinately in these processe...

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Bibliographic Details
Main Authors: Iosefson, Ohad, Nager, Andrew Ross, Baker, Tania, Sauer, Robert T.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/106790
https://orcid.org/0000-0002-1719-5399