Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine
Hexameric ATP-dependent proteases and protein remodeling machines use conserved loops that line the axial pore to apply force to substrates during the mechanical processes of protein unfolding and translocation. Whether loops from multiple subunits act independently or coordinately in these processe...
Main Authors: | Iosefson, Ohad, Nager, Andrew Ross, Baker, Tania, Sauer, Robert T. |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2017
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Online Access: | http://hdl.handle.net/1721.1/106790 https://orcid.org/0000-0002-1719-5399 |
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