Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery

Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery

Thousands of human diseases could be treated by selectively controlling the expression of specific proteins in vivo. A new series of alkenyl amino alcohol (AAA) ionizable lipid nanoparticles (LNPs) capable of delivering human mRNA with unprecedented levels of in vivo efficacy is demonstrated. This s...

Full description

Bibliographic Details
Main Authors: DeRosa, Frank, Langer, Robert, Kauffman, Kevin John, McClellan, Rebecca L, Appel, Eric, Dorkin, Joseph Robert, Tibbitt, Mark W, Langer, Robert S, Anderson, Daniel Griffith, Fenton, Owen Shea
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Wiley Blackwell 2017
Online Access:http://hdl.handle.net/1721.1/106890
https://orcid.org/0000-0002-5585-9280
https://orcid.org/0000-0002-9436-2453
https://orcid.org/0000-0002-2301-7126
https://orcid.org/0000-0002-4917-7187
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0001-5629-4798

Internet

http://hdl.handle.net/1721.1/106890
https://orcid.org/0000-0002-5585-9280
https://orcid.org/0000-0002-9436-2453
https://orcid.org/0000-0002-2301-7126
https://orcid.org/0000-0002-4917-7187
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0001-5629-4798

Similar Items