RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

Myocardial infarction (MI) leads to a systemic surge of vascular inflammation in mice and humans, resulting in secondary ischemic complications and high mortality. We show that, in ApoE−/− mice with coronary ligation, increased sympathetic tone up-regulates not only hematopoietic leukocyte productio...

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Bibliographic Details
Main Authors: Sager, H. B., Dutta, P., Hulsmans, M., Courties, G., Sun, Y., Heidt, T., Vinegoni, C., Borodovsky, A., Fitzgerald, K., Wojtkiewicz, G. R., Iwamoto, Y., Tricot, B., Libby, P., Weissleder, R., Swirski, F. K., Nahrendorf, M., Xing, Yiping, Shaw, Taylor E., Langer, Robert S, Anderson, Daniel Griffith, Khan, Omar Fizal, Kauffman, Kevin John, Dahlman, James E.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2017
Online Access:http://hdl.handle.net/1721.1/106928
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-3811-2369
https://orcid.org/0000-0002-9436-2453

Internet

http://hdl.handle.net/1721.1/106928
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-3811-2369
https://orcid.org/0000-0002-9436-2453

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