High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation

As key components of autocrine signaling, pericellular proteases, a disintegrin and metalloproteinases (ADAMs) in particular, are known to impact the microenvironment of individual cells and have significant implications in various pathological situations including cancer, inflammatory and vascular...

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Bibliographic Details
Main Authors: Wu, Lidan, Claas, Allison Mary, Sarkar, Aniruddh, Lauffenburger, Douglas A, Han, Jongyoon
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Royal Society of Chemistry 2017
Online Access:http://hdl.handle.net/1721.1/106950
https://orcid.org/0000-0003-3150-6170
https://orcid.org/0000-0003-1224-8153
https://orcid.org/0000-0001-7215-1439