Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1

Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1

Proteostasis in the cytosol is governed by the heat shock response. The master regulator of the heat shock response, heat shock factor 1 (HSF1), and key chaperones whose levels are HSF1-regulated have emerged as high-profile targets for therapeutic applications ranging from protein misfolding-relate...

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Bibliographic Details
Main Authors: Moore, Christopher Lawrence, Dewal, Mahender, Nekongo, Emmanuel E, Santiago, Sebasthian, Lu, Nancy B., Levine, Stuart S., Shoulders, Matthew D.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Chemical Society 2017
Online Access:http://hdl.handle.net/1721.1/106953
https://orcid.org/0000-0001-9986-9037
https://orcid.org/0000-0001-7104-0278
https://orcid.org/0000-0002-6511-3431

Internet

http://hdl.handle.net/1721.1/106953
https://orcid.org/0000-0001-9986-9037
https://orcid.org/0000-0001-7104-0278
https://orcid.org/0000-0002-6511-3431

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