A Flow Cytometric Clonogenic Assay Reveals the Single-Cell Potency of Doxorubicin

Standard cell proliferation assays use bulk media drug concentration to ascertain the potency of chemotherapeutic drugs; however, the relevant quantity is clearly the amount of drug actually taken up by the cell. To address this discrepancy, we have developed a flow cytometric clonogenic assay to co...

Full description

Bibliographic Details
Main Authors: Kulkarni, Chethana, Betts, Alison M., Maass, Katie F., Quadir, Mohiuddin Abdul, Hammond, Paula T., Wittrup, Karl Dane
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Wiley Blackwell 2017
Online Access:http://hdl.handle.net/1721.1/107005
https://orcid.org/0000-0002-0493-2863
https://orcid.org/0000-0002-5568-6455
https://orcid.org/0000-0003-2398-5896