Suzuki–Miyaura cross-coupling optimization enabled by automated feedback
An automated, droplet-flow microfluidic system explores and optimizes Pd-catalyzed Suzuki–Miyaura cross-coupling reactions. A smart optimal DoE-based algorithm is implemented to increase the turnover number and yield of the catalytic system considering both discrete variables—palladacycle and ligand...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Royal Society of Chemistry
2017
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| Online Access: | http://hdl.handle.net/1721.1/107128 https://orcid.org/0000-0001-6414-0908 https://orcid.org/0000-0003-3875-4775 https://orcid.org/0000-0001-7192-580X |