Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83
Deficiency of CD83 in thymic epithelial cells (TECs) dramatically impairs thymic CD4 T cell selection. CD83 can exert cell-intrinsic and –extrinsic functions through discrete protein domains, but it remains unclear how CD83’s capacity to operate through these alternative functional modules relates t...
Main Authors: | , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
Rockefeller University Press
2017
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Online Access: | http://hdl.handle.net/1721.1/107138 https://orcid.org/0000-0002-1090-6071 |