Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83

Deficiency of CD83 in thymic epithelial cells (TECs) dramatically impairs thymic CD4 T cell selection. CD83 can exert cell-intrinsic and –extrinsic functions through discrete protein domains, but it remains unclear how CD83’s capacity to operate through these alternative functional modules relates t...

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Bibliographic Details
Main Authors: von Rohrscheidt, Julia, Petrozziello, Elisabetta, Nedjic, Jelena, Federle, Christine, Krzyzak, Lena, Ishido, Satoshi, Steinkasserer, Alexander, Klein, Ludger, Ploegh, Hidde
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Rockefeller University Press 2017
Online Access:http://hdl.handle.net/1721.1/107138
https://orcid.org/0000-0002-1090-6071

Internet

http://hdl.handle.net/1721.1/107138
https://orcid.org/0000-0002-1090-6071

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