Ionizable Amphiphilic Dendrimer-Based Nanomaterials with Alkyl-Chain-Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo

Ionizable Amphiphilic Dendrimer-Based Nanomaterials with Alkyl-Chain-Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo

A library of dendrimers was synthesized and optimized for targeted small interfering RNA (siRNA) delivery to different cell subpopulations within the liver. Using a combinatorial approach, a library of these nanoparticle-forming materials was produced wherein the free amines on multigenerational pol...

Full description

Bibliographic Details
Main Authors: Khan, Omar Fizal, Zaia, Edmond, Yin, Hao, Bogorad, Roman, Pelet, Jeisa, Webber, Matthew, Zhuang, Iris, Langer, Robert S, Anderson, Daniel Griffith, Dahlman, James E.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Wiley Blackwell 2017
Online Access:http://hdl.handle.net/1721.1/107199
https://orcid.org/0000-0003-3811-2369
https://orcid.org/0000-0001-6898-3793
https://orcid.org/0000-0003-0624-3532
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0001-5629-4798

Internet

http://hdl.handle.net/1721.1/107199
https://orcid.org/0000-0003-3811-2369
https://orcid.org/0000-0001-6898-3793
https://orcid.org/0000-0003-0624-3532
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0001-5629-4798

Similar Items