Crystal structure of a substrate-engaged SecY protein-translocation channel

Hydrophobic signal sequences target secretory polypeptides to a protein-conducting channel formed by a heterotrimeric membrane protein complex, the prokaryotic SecY or eukaryotic Sec61 complex. How signal sequences are recognized is poorly understood, particularly because they are diverse in sequenc...

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Bibliographic Details
Main Authors: Li, Long, Park, Eunyong, Rapoport, Tom A., Ling, Jingjing, Ingram, Jessica, Ploegh, Hidde
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Springer Nature 2017
Online Access:http://hdl.handle.net/1721.1/107210
https://orcid.org/0000-0002-0511-4280
https://orcid.org/0000-0002-1090-6071