The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

Alpaca-derived single-domain antibody fragments (VHHs) that target the influenza A virus nucleoprotein (NP) can protect cells from infection when expressed in the cytosol. We found that one such VHH, αNP-VHH1, exhibits antiviral activity similar to that of Mx proteins by blocking nuclear import of i...

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Bibliographic Details
Main Authors: Hanke, Leo, Brewer, R. Camille, van Diest, Eline, Schmidt, Florian I., Schwartz, Thomas, Knockenhauer, Kevin Edward, Ploegh, Hidde
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Society for Microbiology 2017
Online Access:http://hdl.handle.net/1721.1/107392
https://orcid.org/0000-0001-8012-1512
https://orcid.org/0000-0003-2265-5174
https://orcid.org/0000-0002-1090-6071

Internet

http://hdl.handle.net/1721.1/107392
https://orcid.org/0000-0001-8012-1512
https://orcid.org/0000-0003-2265-5174
https://orcid.org/0000-0002-1090-6071

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