Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells

Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells

The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2. PRC2-mediated di- and tri-methylation (H3K27me2/H3K27me3) have been interchangeably associated with gene repression. However, it remains unclear whether these two degrees of H3K27...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Juan, Aster H., Wang, Stan, Ko, Kyung Dae, Zare, Hossein, Tsai, Pei-Fang, Feng, Xuesong, Ascoli, Anthony M., Gutierrez-Cruz, Gustavo, Krebs, Jordan, Sidoli, Simone, Knight, Adam L., Pedersen, Roger A., Garcia, Benjamin A., Casellas, Rafael, Zou, Jizhong, Sartorelli, Vittorio, Vivanco, Karinna O.
Weitere Verfasser: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Artikel
Sprache:en_US
Veröffentlicht: Elsevier 2017
Online Zugang:http://hdl.handle.net/1721.1/107488

Online

http://hdl.handle.net/1721.1/107488

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