Hydrophobic CDR3 residues promote the development of self-reactive T cells

Hydrophobic CDR3 residues promote the development of self-reactive T cells

Studies of individual T cell antigen receptors (TCRs) have shed some light on structural features that underlie self-reactivity. However, the general rules that can be used to predict whether TCRs are self-reactive have not been fully elucidated. Here we found that the interfacial hydrophobicity of...

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Bibliographic Details
Main Authors: Stadinski, Brian D, Shekhar, Karthik, Gómez-Touriño, Iria, Jung, Jonathan, Sasaki, Katsuhiro, Sewell, Andrew K, Peakman, Mark, Chakraborty, Arup K, Huseby, Eric S
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/107650
https://orcid.org/0000-0003-1268-9602

Internet

http://hdl.handle.net/1721.1/107650
https://orcid.org/0000-0003-1268-9602

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