Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia
Data integration stands to improve interpretation of RNAi screens which, as a result of off-target effects, typically yield numerous gene hits of which only a few validate. These off-target effects can result from seed matches to unintended gene targets (reagent-based) or cellular pathways, which ca...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Royal Society of Chemistry
2017
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| Online Access: | http://hdl.handle.net/1721.1/107703 https://orcid.org/0000-0003-4188-0414 https://orcid.org/0000-0001-5024-9718 https://orcid.org/0000-0002-6534-4774 https://orcid.org/0000-0001-9249-8181 |