The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors

The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors

Summary - The transmembrane adaptor PAG (Cbp) has been proposed to mediate membrane recruitment of Csk, a cytoplasmic protein tyrosine kinase playing a critical inhibitory role during T cell activation, by inactivating membrane-associated Src kinases. However, this model has not been validated by ge...

Full description

Bibliographic Details
Main Authors: Davidson, Dominique, Zhong, Ming-Chao, Pandolfi, Pier Paolo, Bolland, Silvia, Seed, Brian, Li, Xin, Gu, Hua, Veillette, André, Xavier, Ramnik Joseph
Other Authors: Massachusetts Institute of Technology. Department of Mechanical Engineering
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/107815

Internet

http://hdl.handle.net/1721.1/107815

Similar Items