Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy

Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy

Alternative splicing is a regulated process that results in expression of specific mRNA and protein isoforms. Alternative splicing factors determine the relative abundance of each isoform. Here we focus on MBNL1, a splicing factor misregulated in the disease myotonic dystrophy. By altering the conce...

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Bibliographic Details
Main Authors: Wagner, Stacey D., Struck, Adam J., Gupta, Riti, Farnsworth, Dylan R., Mahady, Amy E., Eichinger, Katy, Thornton, Charles A., Berglund, J. Andrew, Wang, Eric T
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Public Library of Science 2017
Online Access:http://hdl.handle.net/1721.1/107820

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http://hdl.handle.net/1721.1/107820

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