Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics
Cells are highly dynamic and mechanical automata powered by molecular motors that respond to external cues. Intracellular signaling pathways, either chemical or mechanical, can be activated and spatially coordinated to induce polarized cell states and directional migration. Physiologically, cells na...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
ASME International
2017
|
| Online Access: | http://hdl.handle.net/1721.1/107833 https://orcid.org/0000-0002-6719-9929 https://orcid.org/0000-0001-8462-5080 https://orcid.org/0000-0002-7232-304X |
| _version_ | 1826188799742312448 |
|---|---|
| author | Mak, Michael Spill, Fabian Kamm, Roger Dale Zaman, Muhammad |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Mak, Michael Spill, Fabian Kamm, Roger Dale Zaman, Muhammad |
| author_sort | Mak, Michael |
| collection | MIT |
| description | Cells are highly dynamic and mechanical automata powered by molecular motors that respond to external cues. Intracellular signaling pathways, either chemical or mechanical, can be activated and spatially coordinated to induce polarized cell states and directional migration. Physiologically, cells navigate through complex microenvironments, typically in three-dimensional (3D) fibrillar networks. In diseases, such as metastatic cancer, they invade across physiological barriers and remodel their local environments through force, matrix degradation, synthesis, and reorganization. Important external factors such as dimensionality, confinement, topographical cues, stiffness, and flow impact the behavior of migrating cells and can each regulate motility. Here, we review recent progress in our understanding of single-cell migration in complex microenvironments. |
| first_indexed | 2024-09-23T08:05:13Z |
| format | Article |
| id | mit-1721.1/107833 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:05:13Z |
| publishDate | 2017 |
| publisher | ASME International |
| record_format | dspace |
| spelling | mit-1721.1/1078332022-09-30T07:25:04Z Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics Mak, Michael Spill, Fabian Kamm, Roger Dale Zaman, Muhammad Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Mak, Michael Spill, Fabian Kamm, Roger Dale Zaman, Muhammad Cells are highly dynamic and mechanical automata powered by molecular motors that respond to external cues. Intracellular signaling pathways, either chemical or mechanical, can be activated and spatially coordinated to induce polarized cell states and directional migration. Physiologically, cells navigate through complex microenvironments, typically in three-dimensional (3D) fibrillar networks. In diseases, such as metastatic cancer, they invade across physiological barriers and remodel their local environments through force, matrix degradation, synthesis, and reorganization. Important external factors such as dimensionality, confinement, topographical cues, stiffness, and flow impact the behavior of migrating cells and can each regulate motility. Here, we review recent progress in our understanding of single-cell migration in complex microenvironments. National Cancer Institute (U.S.) (Grant No. 5U01CA177799) National Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award) 2017-04-04T13:42:32Z 2017-04-04T13:42:32Z 2016-02 2015-11 Article http://purl.org/eprint/type/JournalArticle 0148-0731 http://hdl.handle.net/1721.1/107833 Mak, Michael, Fabian Spill, Roger D. Kamm, and Muhammad H. Zaman. “Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics.” Journal of Biomechanical Engineering 138, no. 2 (January 27, 2016): 021004. https://orcid.org/0000-0002-6719-9929 https://orcid.org/0000-0001-8462-5080 https://orcid.org/0000-0002-7232-304X en_US http://dx.doi.org/10.1115/1.4032188 Journal of Biomechanical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf ASME International American Society of Mechanical Engineers (ASME) |
| spellingShingle | Mak, Michael Spill, Fabian Kamm, Roger Dale Zaman, Muhammad Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics |
| title | Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics |
| title_full | Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics |
| title_fullStr | Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics |
| title_full_unstemmed | Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics |
| title_short | Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics |
| title_sort | single cell migration in complex microenvironments mechanics and signaling dynamics |
| url | http://hdl.handle.net/1721.1/107833 https://orcid.org/0000-0002-6719-9929 https://orcid.org/0000-0001-8462-5080 https://orcid.org/0000-0002-7232-304X |
| work_keys_str_mv | AT makmichael singlecellmigrationincomplexmicroenvironmentsmechanicsandsignalingdynamics AT spillfabian singlecellmigrationincomplexmicroenvironmentsmechanicsandsignalingdynamics AT kammrogerdale singlecellmigrationincomplexmicroenvironmentsmechanicsandsignalingdynamics AT zamanmuhammad singlecellmigrationincomplexmicroenvironmentsmechanicsandsignalingdynamics |