A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH) catalyzes the first, ratelimiting step. Genetic lo...

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Bibliographic Details
Main Authors: Chan, Sze Ham, Lewis, Caroline, Swier, Lotteke J. Y. M., Chen, Walter W., Sullivan, Lucas Bryan, Fiske, Brian Prescott, Cho, Sung Won, Abu-Remaileh, Monther, Liu, Chieh Ming Jamin, Zhou, Minerva H., Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Vander Heiden, Matthew G., Sabatini, David, Pacold, Michael Edward
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/107883
https://orcid.org/0000-0003-3688-2378
https://orcid.org/0000-0002-6883-3805
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-6745-8222
https://orcid.org/0000-0002-4236-0229
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/107883
https://orcid.org/0000-0003-3688-2378
https://orcid.org/0000-0002-6883-3805
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-6745-8222
https://orcid.org/0000-0002-4236-0229
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-1446-7256

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