A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH) catalyzes the first, ratelimiting step. Genetic lo...
অনুরূপ উপাদানগুলি
অনুরূপ উপাদানগুলি
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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
অনুযায়ী: Luengo, Alba, অন্যান্য
প্রকাশিত: (2022) -
Increased PHGDH expression promotes aberrant melanin accumulation
অনুযায়ী: Mattaini, Katherine R., অন্যান্য
প্রকাশিত: (2020) -
Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer
অনুযায়ী: Possemato, Richard, অন্যান্য
প্রকাশিত: (2012) -
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
প্রকাশিত: (2021) -
Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation
অনুযায়ী: Diehl, Frances F., অন্যান্য
প্রকাশিত: (2020)