A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH) catalyzes the first, ratelimiting step. Genetic lo...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/107883 https://orcid.org/0000-0003-3688-2378 https://orcid.org/0000-0002-6883-3805 https://orcid.org/0000-0002-7043-5013 https://orcid.org/0000-0002-6745-8222 https://orcid.org/0000-0002-4236-0229 https://orcid.org/0000-0002-6702-4192 https://orcid.org/0000-0002-1446-7256 |