Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

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Machado–Joseph disease (MJD) is a neurodegenerative disorder characterized by an abnormal expansion of the CAG triplet in the ATXN3 gene, translating into a polyglutamine tract within the ataxin-3 protein. The available treatments only ameliorate symptomatology and do not block disease progression....

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Bibliographic Details
Main Authors: Cunha-Santos, Janete, Duarte-Neves, Joana, Carmona, Vitor, Pereira de Almeida, Luís, Cavadas, Cláudia, Guarente, Leonard Pershing
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/107926
https://orcid.org/0000-0003-4064-2510

Internet

http://hdl.handle.net/1721.1/107926
https://orcid.org/0000-0003-4064-2510

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