Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

Show other versions (1)

Machado–Joseph disease (MJD) is a neurodegenerative disorder characterized by an abnormal expansion of the CAG triplet in the ATXN3 gene, translating into a polyglutamine tract within the ataxin-3 protein. The available treatments only ameliorate symptomatology and do not block disease progression....

书目详细资料
Main Authors:	Cunha-Santos, Janete, Duarte-Neves, Joana, Carmona, Vitor, Pereira de Almeida, Luís, Cavadas, Cláudia, Guarente, Leonard Pershing
其他作者:	Massachusetts Institute of Technology. Department of Biology
格式:	文件
语言:	en_US
出版:	Nature Publishing Group 2017
在线阅读:	http://hdl.handle.net/1721.1/107926 https://orcid.org/0000-0003-4064-2510

相似书籍

Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
由: Cunha-Santos, Janete, et al.
出版: (2017)

Machado-Joseph Disease
由: J Gordon Millichap
出版: (1996-06-01)

Machado-Joseph Disease
由: J Gordon Millichap
出版: (1994-10-01)

SIRT1 and other sirtuins in metabolism
由: Chang, Hung-Chun, et al.
出版: (2016)

SIRT1 in Neurodevelopment and Brain Senescence
由: Herskovits, A. Zara, et al.
出版: (2015)

Calorie restriction and sirtuins revisited
由: Guarente, Leonard Pershing
出版: (2014)

The SirT3 Divining Rod Points to Oxidative Stress
由: Bell, Eric L., et al.
出版: (2014)

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
由: Chang, Hung-Chun, et al.
出版: (2015)

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction
由: Chalkiadaki, Angeliki, et al.
出版: (2014)

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2
由: Zainabadi, Kayvan, et al.
出版: (2018)

Metabolic and Neuropsychiatric Effects of Calorie Restriction and Sirtuins
由: Libert, Sergiy V., et al.
出版: (2014)

A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration
由: Graeff, Johannes, et al.
出版: (2017)

A cost analysis of Machado-Joseph's disease (MJD).
由: Cristiane da Silva, et al.
出版: (2024-01-01)

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
由: Nakagawa, Takashi, et al.
出版: (2014)

Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
由: Ulises Edgardo De-Leon-Covarrubias, et al.
出版: (2024-07-01)

SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis
由: Herskovits, A. Zara, et al.
出版: (2020)

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis
由: Zainabadi, Kayvan, et al.
出版: (2018)

SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
由: Donmez Yalcin, Gizem, et al.
出版: (2014)

Machado-Joseph Disease, A Case Report of Treatment Based on Phototherapy
由: Hugo Mendieta Zerón, et al.
出版: (2024-11-01)

Sentinel Node Biopsy and Lumpectomy in a Patient with Machado–Joseph Disease
由: N. N. Aldawoodi, et al.
出版: (2019-01-01)

The effect of caloric restriction on genetical pathways
由: Mustafa Fevzi Karagöz, et al.
出版: (2023-09-01)

Caloric restriction, Sirtuins, and cardiovascular diseases
由: Ziyu Wei, et al.
出版: (2024-04-01)

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
由: Emerling, B. M., et al.
出版: (2013)

The effects of early time restricted eating plus daily caloric restriction compared to daily caloric restriction alone on continuous glucose levels
由: Adnin Zaman, et al.
出版: (2024-02-01)

What is the best way to keep walking and moving around for individuals with Machado-Joseph disease? A scoping review through the lens of Aboriginal families with Machado-Joseph disease in the Top End of Australia
由: Jennifer J Carr, et al.
出版: (2019-09-01)

Collaborative Effects of Caloric Restriction and Quercetin on Age-related Oxidative Stress Reduction through NQO1/Sirt1 Gene Regulation
由: Fereshte Ghorbani, et al.
出版: (2024-12-01)

SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo
由: Bobrowska, Anna, et al.
出版: (2012)

SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones
由: Donmez Yalcin, Gizem, et al.
出版: (2012)

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application
由: Sebastian J Hofer, et al.
出版: (2021-11-01)

Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy
由: Chalkiadaki, Angeliki, et al.
出版: (2014)

A Difficult Case to Diagnose: Machado-Joseph Disease/Spinocerebellar Ataxia Type III
由: Muhammad Sohail Ajmal Ghoauri, et al.
出版: (2023-12-01)

Cognitive deficits in depression: possible implications for functional neuropathology.
由: Austin, M, et al.
出版: (2001)

Sirtuins, Aging, and Medicine
由: Guarente, Leonard Pershing
出版: (2020)

The Logic Linking Protein Acetylation and Metabolism
由: Guarente, Leonard Pershing
出版: (2014)

Forever Young
由: Guarente, Leonard Pershing
出版: (2014)

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis
由: Simic, Petra, et al.
出版: (2014)

Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice
由: Taolin Yuan, et al.
出版: (2024-06-01)

Global DNA methylation is not elevated in blood samples from Machado-Joseph disease mutation carriers
由: Luís Teves, et al.
出版: (2024-12-01)

Enfermagem de reabilitação à pessoa com doença de Machado Joseph: scoping review
由: Teresa Ferreira, et al.
出版: (2023-01-01)

Complementary intestinal mucosa and microbiota responses to caloric restriction
由: Duszka, Kalina, et al.
出版: (2018)