Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism

Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism

T cells reach a state of replicative senescence characterized by a decreased ability to proliferate and respond to foreign antigens. Calcium release associated with TCR engagement is widely used as a surrogate measure of T cell response. Using an ex vivo culture model that partially replicates featu...

Full description

Bibliographic Details
Main Authors: Rivet, Catherine A., Kniss-James, Ariel S., Gran, Margaret A., Potnis, Anish, Hill, Abby, Lu, Hang, Kemp, Melissa L.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2017
Online Access:http://hdl.handle.net/1721.1/107931
https://orcid.org/0000-0002-0093-3236

Internet

http://hdl.handle.net/1721.1/107931
https://orcid.org/0000-0002-0093-3236

Similar Items