Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism
T cells reach a state of replicative senescence characterized by a decreased ability to proliferate and respond to foreign antigens. Calcium release associated with TCR engagement is widely used as a surrogate measure of T cell response. Using an ex vivo culture model that partially replicates featu...
| Autors principals: | , , , , , , |
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| Altres autors: | |
| Format: | Article |
| Idioma: | en_US |
| Publicat: |
Public Library of Science
2017
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| Accés en línia: | http://hdl.handle.net/1721.1/107931 https://orcid.org/0000-0002-0093-3236 |