Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs

Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs

Therapeutic nucleic acids hold great promise for the treatment of disease but require vectors for safe and effective delivery. Synthetic nanoparticle vectors composed of poly(β-amino esters) (PBAEs) and nucleic acids have previously demonstrated potential utility for local delivery applications. To...

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Bibliographic Details
Main Authors: Heartlein, Michael W., DeRosa, Frank, Kaczmarek, James Cliff, Kauffman, Kevin John, Webber, Matthew, Anderson, Daniel Griffith, Patel, Asha, Fenton, Owen Shea
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Wiley Blackwell 2017
Online Access:http://hdl.handle.net/1721.1/107933
https://orcid.org/0000-0002-6516-7499
https://orcid.org/0000-0002-7266-9251
https://orcid.org/0000-0002-9436-2453
https://orcid.org/0000-0002-5585-9280
https://orcid.org/0000-0003-0624-3532
https://orcid.org/0000-0001-5629-4798

Internet

http://hdl.handle.net/1721.1/107933
https://orcid.org/0000-0002-6516-7499
https://orcid.org/0000-0002-7266-9251
https://orcid.org/0000-0002-9436-2453
https://orcid.org/0000-0002-5585-9280
https://orcid.org/0000-0003-0624-3532
https://orcid.org/0000-0001-5629-4798

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