Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs
Therapeutic nucleic acids hold great promise for the treatment of disease but require vectors for safe and effective delivery. Synthetic nanoparticle vectors composed of poly(β-amino esters) (PBAEs) and nucleic acids have previously demonstrated potential utility for local delivery applications. To...
Main Authors: | Heartlein, Michael W., DeRosa, Frank, Kaczmarek, James Cliff, Kauffman, Kevin John, Webber, Matthew, Anderson, Daniel Griffith, Patel, Asha, Fenton, Owen Shea |
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Other Authors: | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
Format: | Article |
Language: | en_US |
Published: |
Wiley Blackwell
2017
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Online Access: | http://hdl.handle.net/1721.1/107933 https://orcid.org/0000-0002-6516-7499 https://orcid.org/0000-0002-7266-9251 https://orcid.org/0000-0002-9436-2453 https://orcid.org/0000-0002-5585-9280 https://orcid.org/0000-0003-0624-3532 https://orcid.org/0000-0001-5629-4798 |
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