MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

Rather than targeting tumour cells directly, elements of the tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here we report a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death. Using...

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Bibliographic Details
Main Authors: Wilson, RaeAnna, Espinosa-Diez, Cristina, Kanner, Nathan, Chatterjee, Namita, Ruhl, Rebecca, Hipfinger, Christina, Advani, Sunil J., Li, Jie, Franovic, Aleksandra, Weis, Sara M., Coussens, Lisa M., Chen, Clark C., Cheresh, David A., Anand, Sudarshan, Khan, Omar Fizal, Anderson, Daniel Griffith, Kumar, Sushil, Ph. D. Massachusetts Institute of Technology
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/107950
https://orcid.org/0000-0003-3811-2369
https://orcid.org/0000-0001-5629-4798

Internet

http://hdl.handle.net/1721.1/107950
https://orcid.org/0000-0003-3811-2369
https://orcid.org/0000-0001-5629-4798

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