A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton

Wiskott-Aldrich syndrome (WAS) is associated with mutations in the WAS protein (WASp), which plays a critical role in the initiation of T cell receptor–driven (TCR-driven) actin polymerization. The clinical phenotype of WAS includes susceptibility to infection, allergy, autoimmunity, and malignancy...

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Bibliographic Details
Main Authors: Janssen, Erin, Tohme, Mira, Hedayat, Mona, Leick, Marion, Ramesh, Narayanaswamy, Massaad, Michel J., Ullas, Sumana, Azcutia, Veronica, Goodnow, Christopher C., Randall, Katrina L., Qiao, Qi, Wu, Hao, Al-Herz, Waleed, Cox, Dianne, Hartwig, John, Luscinskas, Francis W., Geha, Raif S., Kumari, Sudha, Irvine, Darrell J
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Society for Clinical Investigation 2017
Online Access:http://hdl.handle.net/1721.1/107953
https://orcid.org/0000-0003-2705-7245

Internet

http://hdl.handle.net/1721.1/107953
https://orcid.org/0000-0003-2705-7245

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