Interleukins 7 and 15 Maintain Human T Cell Proliferative Capacity through STAT5 Signaling

Interleukins 7 and 15 Maintain Human T Cell Proliferative Capacity through STAT5 Signaling

T lymphocytes require signals from self-peptides and cytokines, most notably interleukins 7 and 15 (IL-7, IL-15), for survival. While mouse T cells die rapidly if IL-7 or IL-15 is withdrawn, human T cells can survive prolonged withdrawal of IL-7 and IL-15. Here we show that IL-7 and IL-15 are requir...

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Bibliographic Details
Main Authors: Drake, Adam, Kaur, Mandeep, Iliopoulou, Bettina P., Phennicie, Ryan, Hanson, Amanda, Chen, Jianzhu, Phennicie, Ryan T.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Public Library of Science 2017
Online Access:http://hdl.handle.net/1721.1/107955
https://orcid.org/0000-0001-9816-2187
https://orcid.org/0000-0002-5687-6154

Internet

http://hdl.handle.net/1721.1/107955
https://orcid.org/0000-0001-9816-2187
https://orcid.org/0000-0002-5687-6154

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