Sestrin2 is a leucine sensor for the mTORC1 pathway
Leucine is a proteogenic amino acid that also regulates many aspects of mammalian physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a master growth controller. Amino acids signal to mTORC1 through the Rag guanosine triphosphatases (GTPases). Several factors regulate...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Association for the Advancement of Science (AAAS)
2017
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| Online Access: | http://hdl.handle.net/1721.1/107960 https://orcid.org/0000-0002-9535-7664 https://orcid.org/0000-0001-9388-1633 https://orcid.org/0000-0002-9376-3984 https://orcid.org/0000-0002-1446-7256 |