Assessment of megabase-scale somatic copy number variation using single-cell sequencing
Megabase-scale copy number variants (CNVs) can have profound phenotypic consequences. Germline CNVs of this magnitude are associated with disease and experience negative selection. However, it is unknown whether organismal function requires that every cell maintain a balanced genome. It is possible...
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Format: | Article |
Language: | en_US |
Published: |
Cold Spring Harbor Laboratory Press
2017
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Online Access: | http://hdl.handle.net/1721.1/108070 https://orcid.org/0000-0003-0649-7428 https://orcid.org/0000-0002-0989-8115 https://orcid.org/0000-0001-9837-0314 |