Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

Eukaryotic cells coordinate growth with the availability of nutrients through the mechanistic target of rapamycin complex 1 (mTORC1), a master growth regulator. Leucine is of particular importance and activates mTORC1 via the Rag guanosine triphosphatases and their regulators GATOR1 and GATOR2. Sest...

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Bibliographic Details
Main Authors: Saxton, Robert Andrew, Wolfson, Rachel Laura, Chantranupong, Lynne, Wang, Tim, Schwartz, Thomas, Sabatini, David, Knockenhauer, Kevin Edward, Pacold, Michael Edward
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2017
Online Access:http://hdl.handle.net/1721.1/108103
https://orcid.org/0000-0002-9376-3984
https://orcid.org/0000-0002-9535-7664
https://orcid.org/0000-0001-9388-1633
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0001-8012-1512
https://orcid.org/0000-0002-1446-7256
https://orcid.org/0000-0003-2265-5174
https://orcid.org/0000-0003-3688-2378

Internet

http://hdl.handle.net/1721.1/108103
https://orcid.org/0000-0002-9376-3984
https://orcid.org/0000-0002-9535-7664
https://orcid.org/0000-0001-9388-1633
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0001-8012-1512
https://orcid.org/0000-0002-1446-7256
https://orcid.org/0000-0003-2265-5174
https://orcid.org/0000-0003-3688-2378

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