Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
Eukaryotic cells coordinate growth with the availability of nutrients through the mechanistic target of rapamycin complex 1 (mTORC1), a master growth regulator. Leucine is of particular importance and activates mTORC1 via the Rag guanosine triphosphatases and their regulators GATOR1 and GATOR2. Sest...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Association for the Advancement of Science (AAAS)
2017
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| Online Access: | http://hdl.handle.net/1721.1/108103 https://orcid.org/0000-0002-9376-3984 https://orcid.org/0000-0002-9535-7664 https://orcid.org/0000-0001-9388-1633 https://orcid.org/0000-0002-4227-5163 https://orcid.org/0000-0001-8012-1512 https://orcid.org/0000-0002-1446-7256 https://orcid.org/0000-0003-2265-5174 https://orcid.org/0000-0003-3688-2378 |