Atomic structure of anthrax protective antigen pore elucidates toxin translocation

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Protective antigen forms oligomeric prepores that undergo conversion to membrane-spanning pores by endosomal...

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Bibliographic Details
Main Authors: Jiang, Jiansen, Pentelute, Bradley L., Zhou, Z. Hong, Collier, Robert John
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/108165