Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer

Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer

Runt domain transcription factor 3 (RUNX3) is widely regarded as a tumour-suppressor gene inactivated by DNA hypermethylation of its canonical CpG (cytidine-phosphate-guanidine) island (CGI) promoter in gastric cancer (GC). Absence of RUNX3 expression from normal gastric epithelial cells (GECs), the...

Full description

Bibliographic Details
Main Authors: Kurklu, B, Whitehead, R H, Ong, E K, Minamoto, T, Mann, J R, Judd, L M, Giraud, A S, Menheniott, T R, Fox, James G
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/108192
https://orcid.org/0000-0001-9307-6116

Internet

http://hdl.handle.net/1721.1/108192
https://orcid.org/0000-0001-9307-6116

Similar Items