Targeting MTHFD2 in acute myeloid leukemia

Targeting MTHFD2 in acute myeloid leukemia

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Drugs targeting metabolism have formed the backbone of therapy for some cancers. We sought to identify new such targets in acute myeloid leukemia (AML). The one-carbon folate pathway, specifically methylenetetrahydrofolate dehydrogenase-cyclohydrolase 2 (MTHFD2), emerged as a top candidate in our an...

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Bibliographic Details
Main Authors: Pikman, Yana, Alexe, Gabriela, Furman, Andrew, Chen, Liying M., Frumm, Stacey M., Ross, Linda, Fenouille, Nina, Bassil, Christopher F., Gould, Joshua, Stone, Richard M., DeAngelo, Daniel J., Galinsky, Ilene, Clish, Clary B., Kung, Andrew L., Banerji, Versha, Stegmaier, Kimberly, Puissant, Alexandre, Lewis, Caroline, Ramos, Azucena, Hemann, Michael, Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Wiley Blackwell 2017
Online Access:http://hdl.handle.net/1721.1/108198
https://orcid.org/0000-0002-6883-3805
https://orcid.org/0000-0001-7168-8672
https://orcid.org/0000-0002-6702-4192

Internet

http://hdl.handle.net/1721.1/108198
https://orcid.org/0000-0002-6883-3805
https://orcid.org/0000-0001-7168-8672
https://orcid.org/0000-0002-6702-4192

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