TET1 is a tumor suppressor of hematopoietic malignancy

TET1 is a tumor suppressor of hematopoietic malignancy

The methylcytosine dioxygenase TET1 (‘ten-eleven translocation 1’) is an important regulator of 5-hydroxymethylcytosine (5hmC) in embryonic stem cells. The diminished expression of TET proteins and loss of 5hmC in many tumors suggests a critical role for the maintenance of this epigenetic modificati...

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Bibliographic Details
Main Authors: Cimmino, Luisa, Ndiaye-Lobry, Delphine, Yap, Yoon Sing, Bakogianni, Sofia, Yu, Yiting, Bhattacharyya, Sanchari, Shaknovich, Rita, Geng, Huimin, Lobry, Camille, Mullenders, Jasper, King, Bryan, Trimarchi, Thomas, Aranda-Orgilles, Beatriz, Liu, Cynthia, Shen, Steven, Verma, Amit K, Aifantis, Iannis, Dawlaty, Meelad M, Jaenisch, Rudolf
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/108307

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http://hdl.handle.net/1721.1/108307

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