Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer

Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer

Ribonucleotide reductases (RNRs) are responsible for all de novo biosynthesis of DNA precursors in nature by catalyzing the conversion of ribonucleotides to deoxyribonucleotides. Because of its essential role in cell division, human RNR is a target for a number of anticancer drugs in clinical use. L...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Asturias, Francisco J., Ando, Nozomi, Li, Haoran, Brignole, Edward J, Thompson, Samuel M., McLaughlin, Martin I., Page, Julia E., Stubbe, JoAnne, Drennan, Catherine L.
Muut tekijät: Massachusetts Institute of Technology. Department of Biology
Aineistotyyppi: Artikkeli
Kieli:en_US
Julkaistu: American Chemical Society (ACS) 2017
Linkit:http://hdl.handle.net/1721.1/108309
https://orcid.org/0000-0001-8076-4489
https://orcid.org/0000-0001-5486-2755

Internet

http://hdl.handle.net/1721.1/108309
https://orcid.org/0000-0001-8076-4489
https://orcid.org/0000-0001-5486-2755

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