Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer

Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer

Ribonucleotide reductases (RNRs) are responsible for all de novo biosynthesis of DNA precursors in nature by catalyzing the conversion of ribonucleotides to deoxyribonucleotides. Because of its essential role in cell division, human RNR is a target for a number of anticancer drugs in clinical use. L...

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Bibliographic Details
Main Authors:	Asturias, Francisco J., Ando, Nozomi, Li, Haoran, Brignole, Edward J, Thompson, Samuel M., McLaughlin, Martin I., Page, Julia E., Stubbe, JoAnne, Drennan, Catherine L.
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	American Chemical Society (ACS) 2017
Online Access:	http://hdl.handle.net/1721.1/108309 https://orcid.org/0000-0001-8076-4489 https://orcid.org/0000-0001-5486-2755

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