Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo
Aneuploidy, an imbalanced karyotype, is a widely observed feature of cancer cells that has long been hypothesized to promote tumorigenesis. Here we evaluate the fitness of cells with constitutional trisomy or chromosomal instability (CIN) in vivo using hematopoietic reconstitution experiments. We di...
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| Aineistotyyppi: | Artikkeli |
| Kieli: | en_US |
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Cold Spring Harbor Laboratory Press
2017
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| Linkit: | http://hdl.handle.net/1721.1/108393 https://orcid.org/0000-0002-4698-2746 https://orcid.org/0000-0002-5655-2176 https://orcid.org/0000-0003-0649-7428 https://orcid.org/0000-0001-9837-0314 |