Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo

Aneuploidy, an imbalanced karyotype, is a widely observed feature of cancer cells that has long been hypothesized to promote tumorigenesis. Here we evaluate the fitness of cells with constitutional trisomy or chromosomal instability (CIN) in vivo using hematopoietic reconstitution experiments. We di...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Pfau, Sarah Jeanne, Silberman, Rebecca Estelle, Knouse, Kristin Ann, Amon, Angelika B.
Άλλοι συγγραφείς: Harvard University--MIT Division of Health Sciences and Technology
Μορφή: Άρθρο
Γλώσσα:en_US
Έκδοση: Cold Spring Harbor Laboratory Press 2017
Διαθέσιμο Online:http://hdl.handle.net/1721.1/108393
https://orcid.org/0000-0002-4698-2746
https://orcid.org/0000-0002-5655-2176
https://orcid.org/0000-0003-0649-7428
https://orcid.org/0000-0001-9837-0314