Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

Genome-wide association studies (GWAS) have identified numerous genetic variants associated with complex diseases, but mechanistic insights are impeded by a lack of understanding of how specific risk variants functionally contribute to the underlying pathogenesis. It has been proposed that cis-actin...

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Detalhes bibliográficos
Principais autores: Soldner, Frank, Stelzer, Yonatan, Abraham, Brian J., Latourelle, Jeanne C., Barrasa, M. Inmaculada, Goldmann, Johanna, Myers, Richard H., Jaenisch, Rudolf, Shivalila, Chikdu Shakti, Young, Richard A.
Outros Autores: Massachusetts Institute of Technology. Department of Biology
Formato: Artigo
Idioma:en_US
Publicado em: Nature Publishing Group 2017
Acesso em linha:http://hdl.handle.net/1721.1/108430
https://orcid.org/0000-0001-8855-8647
https://orcid.org/0000-0002-2905-0306

Internet

http://hdl.handle.net/1721.1/108430
https://orcid.org/0000-0001-8855-8647
https://orcid.org/0000-0002-2905-0306

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