DNA sense-and-respond protein modules for mammalian cells

DNA sense-and-respond protein modules for mammalian cells

We generated synthetic protein components that can detect specific DNA sequences and subsequently trigger a desired intracellular response. These modular sensors exploit the programmability of zinc-finger DNA recognition to drive the intein-mediated splicing of an artificial trans-activator that sig...

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Bibliographic Details
Main Authors: Slomovic, Shimyn, Collins, James J.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/108502
https://orcid.org/0000-0003-4873-3222
https://orcid.org/0000-0002-5560-8246

Internet

http://hdl.handle.net/1721.1/108502
https://orcid.org/0000-0003-4873-3222
https://orcid.org/0000-0002-5560-8246

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