SIKs control osteocyte responses to parathyroid hormone

SIKs control osteocyte responses to parathyroid hormone

Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation and resorption. Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH stimulation of RANKL, a stimulator of bone resorption, requires CRTC2. Salt inducib...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Wein, Marc N., Liang, Yanke, Goransson, Olga, Sundberg, Thomas B., Wang, Jinhua, Williams, Elizabeth A., O’Meara, Maureen J., Govea, Nicolas, Beqo, Belinda, Nishimori, Shigeki, Nagano, Kenichi, Brooks, Daniel J., Martins, Janaina S., Corbin, Braden, Anselmo, Anthony, Sadreyev, Ruslan, Wu, Joy Y., Sakamoto, Kei, Foretz, Marc, Baron, Roland, Bouxsein, Mary L., Gardella, Thomas J., Divieti-Pajevic, Paola, Gray, Nathanael S., Kronenberg, Henry M., Xavier, Ramnik Joseph
مؤلفون آخرون: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
التنسيق: مقال
اللغة:en_US
منشور في: Nature Publishing Group 2017
الوصول للمادة أونلاين:http://hdl.handle.net/1721.1/108567

الانترنت

http://hdl.handle.net/1721.1/108567

مواد مشابهة